The Anti-PLD1 Antibody from MyBioSource.com is a Polyclonal antibody to Phospholipase D1, and PLD1. This antibody recognizes Human, and Mouse antigen. The Anti-PLD1 Antibody has been validated for the following applications: Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Phospholipase D1(PLD1) detection. Tested with WB in Human;Mouse.
Background: By somatic cell hybrid analysis, PLD1 is mapped to 3q26.31. This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. And PLD1 disrupted association of gamma-secretase protein components, independent of PLD1catalytic activity. What's more, PLD1 regulates intracellular trafficking of beta-amyloid, distinct from its effect on gamma-secretase activity